分子影像学英文版-瑞金医学影像学精品课.ppt

Molecular Imaging andGenomics Molecular Imaging Components Fundamental Technology Hurdles Platform Concepts Disease Targets Industry and Academic Partnerships Project Definition Molecular Tools CV: Myocardial Infarction Comprehensive Molecular Diagnostics Program in Cardiovascular Disease Approach Basis of research focus and target selection Largest unmet clinical need Diagnostic affects therapy choice outcome Surrogate for disease modifying claims Diagnostic-therapeutic co-development Development of molecular imaging agent(s) Development of clinical IVD test CNS Disease: Comprehensive Imaging Program Expanding to Diagnostic Agents Approach and opportunity Opportunity: disease modifying therapy pipeline Early differential diagnosis Diagnosis to affect therapy choice outcome Surrogate for disease modifying claims Diagnostic-therapeutic co-development Application of high field (3T) MRI Development of molecular imaging agent(s) Disease pathogenesis molecular mechanisms Long and Narrow Linear Molecules Could Penetrate Tumor Endothelium Brain Tissue Characterization: Identify Biomarkers and Develop Insights into Disease Pathology Bioinformatics: Pathway Elucidation G e n o m i c s a n d M o l e c u l a r I m a g i n g Radiology Dept. , Ruijin Hospital Molecular Imaging Imageology Radiology Technology development to spearhead the revolution in medicine….. DNA/Protein MicroArrays Affymetrix Integrated Diagnostics: in Vivo Imaging tied to Applied Genomics Source: Uzgiris, GE CRD Tjuvajev, Blasberg, Larson, MSKCC Drugs needing more specific disease diagnosis or genetic data on patient Chemistry libraries Novel agents/tracers Biochemistry Pharmacology MOLECULAR IMAGING Molecular Biology PET, MRI, MRSI Core Technologies: Hi Sens/Spec Imaging Image Analysis Imaging Physics, Engineering Integrating Critical Skills… Imaging with Diagnostics … Diagnostics with Therapeutics Technology Focus Areas: MR and PET Diagnostic Agents Biomarker Discovery and C