【2017年整理】修改正文.doc.doc

子宫动脉灌注新辅助化疗在Ⅱ期宫颈癌治疗中的临床分析 研究生：古力米热.乃扎尔 导师：程静新摘要 目的：探讨子宫动脉灌注新辅助化疗在Ⅱ期宫颈癌治疗中的可行性及疗效。方法：回顾性分析从2005年9月至2008年6月在新疆医科大学附属肿瘤医院住院治疗的116例病理证实的Ⅱa-Ⅱb期宫颈癌患者采用顺铂表阿霉素5-氟尿嘧啶行1-2周期超选择性子宫动脉插管化疗，介入化疗后86例患者行宫颈癌根治术，30例行放疗，介入化疗后行宫颈癌根治术的86例患者为实验组，选择同期单纯手术治疗的Ⅱa-Ⅱb期宫颈癌患者80例为对照组，比较两组患者病理组织学特点，术中，术后情况。结果：介入化疗后宫颈局部及宫旁均有不同程度的改善，Ⅱ期宫颈癌患者近期有效率为74.14℅;组织学完全缓解率为4.65℅。介入后手术组与对照组患者比较，病理高危因素、手术时间、术中出血量无差异（P＞0.05）术后并发症的发生低于手术组术后并发症发生有统计学差异（P＜0.05）。结论：中晚期宫颈癌治疗中,选择性子宫动脉灌注新辅助化疗不失为一种微创、安全、有效的治疗措施。可有效缩小局部肿瘤体积和改善宫旁条件，提高手术切除率，术后并发症的发生率。长期疗效待进一步研究。 关键词：宫颈癌动脉灌注新辅助化疗根治术Clinical analysis of intra uterine arterial neoadjuvant chemotherapy for stageⅡcervical cancer Postgraduate: gulimire. naizhaer Supervisor: Vice Prof.cheng jing-xin Abstract Objective: To study the curative effects and feasibility of pre - operative intra uterine arterial neoadjuvant chemotherapy in patients for stage Ⅱcervical cancer. Methods: A retrospective study 116 patients with FIGO stage Ⅱa ～ Ⅱb cervical cancer were performed intra - arterial neoadjuvant chemotherapy with DDP,5-FU, EPI for 1-2 cycles during the period of September 2005 and June 2008 at Xinjang tumor hospital , 2-3weeks after 86 patients followed radical operation and 30 patients followed radiotherapy. The study group (n=86) underwent surgery following intra uterine arterial neoadjuvant chemotherapy while control group (n=80) were selected among the patient of cervical cancer performed operations without chemotherapy. Compared two groups of pathological risk factor, operation time, bleeding amounts and operative complication. Results: After intra uterine arterial neoadjuvant chemotherapy, The tumor size reduced significantly, the rates of complete response plus partial response were 74.14%, pathological complete responses were found in 4 cases(4.65%); there are no significant differences in operation bleeding amounts ,operation time and pathological risk factor between two groups. Compared with the control group, incidence of operative complications were statistically