一锅法制备1-(2,3-二氯苯基)哌嗪盐酸盐.pdf

第20 卷第4 期 江 苏 工 业 学 院 学 报 Vol1 20 No1 4 2008 年12 月 JOURNAL OF JIANGSU POLYTECHNIC UNIVERSITY Dec1 2008 : 167 - 9620 (2008) 04- 00 2- 04 * 1- ( 2, - ) , , ( , 21 164) : 1- ( 2, - ) , B, Bc - , 2, - , 1- ( 2, - ) 481 % , 9517% , , : 1- ( 2, - ) ; ; : O 6261415 : A One Pot Synthesis of 1- (2, - Dichlorophenyl) Piperazinium Chloride ZHU Xiao- bin, XU Chong- fu, CHEN Miao ( School of Chemistry and Chemical Engineering, Jiangsu Polytechnic University, Changzhou 21 164, China) Abstract: 1- ( 2, - Dichlorophenyl) piperazinium chloride is an important pharmaceutical intermed-i ate. Diethanolamine w as chlorinated w ithout solvent to generate B, Bc- dichlorodiethylammonium chloride in situ, follow ed by addition of 2, - dichloroaniline and a phase transfer catalyst to cyclolize and yield the targeted compound 1- ( 2, - dichlorophenyl) piperazinium chloride w ith 481 % yield and 9517% pur-i ty . T he structure of the product w as consistent w ith that of the expected result by IR and NM R spectros- copy. The process applied w as environment benign, time- saving and operation friendly . Key words: 1- ( 2, - Dichlorophenyl) piperazinium chloride; one pot reaction; phase transfer catalyst 5- HT , , [ 1, 2] , ; , ; , 1- ( 2, - ) , , , [ 6- 9] , : ¹ , [ ] [ 4] ; º ; »2, 6- B, Bc- , 2, [ 5] - , ,