超分割放射治疗食管癌临床疗效观察.doc

超分割放射治疗食管癌临床疗效观察[摘要] 目的：探讨超分割放射治疗食管癌的放疗疗效和急性放射反应。方法：将56例食管癌随机分成超分割放疗（HF）组和常规分割放疗（CF）组，采用6 MV直线加速器（前胸1个正中野和后背2个斜野）照射。结果：超分割放疗组1、2、3年生存率分别为75.0%、53.6%和39.2%，明显优于常规分割放疗组的46.4%、28.6%和21.4%（P＜0.05）；超分割放疗组1、2、3年局部控制率分别为82.1%、67.9%和46.4%，显著高于常规放疗组的53.6%、32.1%和21.4%（P＜0.05）；两组急性放射反应及早期并发症无明显差异（P＞0.05）。超分割放疗组和常规分割放疗组因局部复发而死亡者分别为64.7%和69.6%，差异无统计学意义（P＞0.05）。结论：超分割放射治疗技术能明显提高食管癌局部控制率和生存率，没有增加患者的急性放射反应，患者耐受性好，是一种安全、有效的治疗方法，值得推广。 [关键词] 食管癌；超分割放射治疗；常规放射治疗 [中图分类号] R735.1 [文献标识码]Ａ [文章编号]1673-7210（2011）03（b）-041-03 Clinical observation of hyperfractionated radiotherapy for esophageal cancer patients MENG Chunyan Department of Hematology Oncology, the First People’s Hospital of Siping City, Siping 136001, China [Abstract] Objective: To evaluate the efficacy of hyperfractioned radiotherapy for esophageal cancer radiotherapy and acute radiation reaction. Methods: 56 patients with esophageal cancer were randomly divided into hyperfractionated radiotherapy (HF) group and conventional radiotherapy (CF) group, using 6 MV linear accelerator (the middle of the chest an illicit sexual relations back two oblique field) irradiation. Results: The hyperfractionated radiotherapy group 1, 2, 3 year survival rates were 75.0%, 53.6% and 39.2% respectively, significantly superior to conventional fractionated radiotherapy group of 46.4%, 28.6% and 21.4% (P0.05). Hyperfractionated radiotherapy and conventional radiotherapy group of those who died due to local recurrence were 64.7% and 69.6%, there was no significant difference (P0.05). Conclusion: Hyperfractionated radiation therapy can significantly improve local control and survival rates of esophageal cancer, and not increase in patients with acute radiation response, the tolerance is good, it is a safe and effective method, and worthy of promotion. [Key words] Esophageal cancer; Hyperfractioned radiotherapy; Conventional radiotherapy 食管癌是一种常见的恶性消化道肿瘤，全世界每年约有30万人死于食管癌，我国占半数以上，是世界上食管癌发病率和死亡率最高的国家之一。2000年我国癌症死亡人数约150万，其中，食管癌的死亡在