医药化工中的一些重要吲哚化合物_徐兆瑜.pdf

年第 期 精细化工原料及中间体 中间体 2009 1 - 27 - 医药化工中的一些重要吲哚化合物 徐兆瑜 （安徽省化工研究院， 安徽合肥， 230041 ） 摘 要： 介绍了吲哚及十几种吲哚化合物的性质、合成方法以及在医药领域中的应用简况，这些吲哚衍生 物如： 醛基吲哚 甲酸乙酯， 甲氧基吲哚， ， ， 二吲哚甲烷（ ）等。 许多吲哚及其衍生物在治疗 3- －5－ 5－ 3 3 － DIM 癌症，艾滋病、心血管疾病以及骨风湿性疾病、消炎、镇痛等医药治疗方面取得了显著成就，故对其相关化合 物作了重点叙述。 例如： 负载 酸催化合成 甲基吲哚， 甲氧基吲哚，吲哚甲基海英的合成 MCM-41 Lewis 2- 5- 等。 已经表明，吲哚及其衍生物在医药化工领域中的应用具有很好的前景，值得引起关注和进一步研究和开 发。 关键词： 吲哚 医药 中间体 生物活性 Important Indole Compound In the Pharmaceutical Chemicals XU Zhao-yu ( Anhui Research Institute of Chemical Industry, Hefei 230041) Abstract: Recent significant research and development on the Indole Compound for medicine, medicine intermediates and other usefuless were summarized in this paper.their including ethyl-3-formylindole -5-car- boxylate, 3-formylindole-7-carboxylic acid, 5-bromo-1-methylisatin, Indolmethyl-Hydantoic, 5-meyhoxyin- dole, 3 －Dimethylaminomethylidole, trans -5-methyloxy-3-styrenylindole et al. Be worth attention several of Indole derivative assume resist AIDS, Cancer, treatment heart blood －vessel, antiphlogistic, analgesics and Arthritis disease action, or immunoincreasing actvities were have been discover, for example: 5－methoxy indole, DIM, etc. The correlation products were described emphatically, for example, the 2 －methylindole was synthesized by cy- ， clization reaction from phenylhydrazine and acetone catalyzed by MCM －41 molecular sieves which were sup-