telomeric trans-silencing in drosophila melanogaster tissue specificity, development and functional interactions between non-homologous telomeres端粒的trans-silencing在黑腹果蝇组织特异性、发展和功能异源染色体端粒之间的相互作用.pdf
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Telomeric Trans-Silencing in Drosophila melanogaster:
Tissue Specificity, Development and Functional
Interactions between Non-Homologous Telomeres
Thibaut Josse1¤a, Corinne Maurel-Zaffran1¤b, Augustin de Vanssay1,2, Laure Teysset1,2, Anne-Laure
1,2 1,2 3 ´ ` 1 ´
Todeschini , Valerie Delmarre , Nicole Chaminade , Dominique Anxolabehere , Stephane
Ronsseray1,2*
´ ´
1 Laboratoire ‘‘Dynamique du Genome et Evolution’’, Institut Jacques Monod, UMR7592, CNRS-Universites Paris 6 et 7, Paris, France, 2 Laboratoire ‘‘Biologie du
´ ´ ´ ´ ˆ
Developpement’’, UMR7622, CNRS-Universite Paris 6, Paris, France, 3 Laboratoire ‘‘Evolution, Genomes, Speciation’’, CNRS UPR 9034, Bat 13, Gif sur Yvette, France
Abstract
Background: The study of P element repression in Drosophila melanogaster led to the discovery of the telomeric Trans-
Silencing Effect (TSE), a homology-dependent repression mechanism by which a P-transgene inserted in subtelomeric
heterochromatin (Telomeric Associated Sequences, ‘‘TAS’’) has the capacity to repress in trans, in the female germline, a
homologous P-lacZ transgene located in euchromatin. TSE can show variegation in ovaries, displays a maternal effect as well
as an epigenetic transmission through meiosis and involves heterochromatin and RNA silencing pathways.
Principal Findings: Here, we analyze phenotypic and genetic properties of TSE. We report that TSE does not occur in the
soma at the adult stage, but appears restricted to the female g
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