white matter abnormalities in major depression a tract-based spatial statistics and rumination study白质异常抑郁症tract-based空间统计和沉思的研究.pdf

White Matter Abnormalities in Major Depression: A Tract- Based Spatial Statistics and Rumination Study 1. 2. 3 4 2 3 2 Nianming Zuo , Jiliang Fang , Xueyu Lv , Yuan Zhou , Yang Hong , Tao Li , Haibing Tong , 2 3 1,5,6 Xiaoling Wang , Weidong Wang *, Tianzi Jiang * 1 LIAMA Center for Computational Medicine, National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing, China, 2 Laboratory for Functional Brain Imaging, Department of Radiology, Guang-an-men Hospital, China Academy of Chinese Medical Sciences, Beijing, China, 3 Department of Psychology, Guang-an-men Hospital, China Academy of Chinese Medical Sciences, Beijing, China, 4 Key Laboratory of Behavioral Science, Institute of Psychology, Chinese Academy of Sciences, Beijing, China, 5 Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China, 6 The Queensland Brain Institute, The University of Queensland, Brisbane, Queensland, Australia Abstract Increasing evidence indicates that major depressive disorder (MDD) is usually accompanied by altered white matter in the prefrontal cortex, the parietal lobe and the limbic system. As a behavioral abnormity of MDD, rumination has been believed to be a substantial indicator of the mental state of the depressive state. So far, however, no report that we are aware of has evaluated the relationship between white matter alterations and the ruminative state. In this study, we first explored the altered white matter using a tract-based spatial statistics (TBSS) me