牙周炎与p38丝裂原活化蛋白激酶通路的研究与进展.doc

牙周炎与p38丝裂原活化蛋白激酶通路的研究与进展 唐亚平，刘 琪，郭成伟，谢瑞娣(遵义医学院附属口腔医院牙周科，贵州省遵义市 563003) 引用本文：唐亚平，刘琪，郭成伟，谢瑞娣. 牙周炎与p38丝裂原活化蛋白激酶通路的研究与进展[J].中国组织工程研究，2016，20(51):7746-7752 DOI: 10.3969/j.issn.2095-4344.2016.51.022 ORCID: 0000-0001-9734-5467(刘琪) 文章快速阅读： 文题释义： 牙周炎p38丝裂原活化蛋白激酶κB受体活化因子配体；牙周膜干细胞；阻断剂；炎症；免疫；修复 主题词： 组织工程；牙周炎；炎症；免疫 基金资助： 国家自然科学基金 缩略语： p38丝裂原活化蛋白激酶：p38 mitogen activated protein kinase，p38MAPK；核因子κB受体活化因子配体receptor activator for nuclear factor-κB ligand，RANKLPeriodontitis and p38 mitogen activated protein kinase pathway: research and development Tang Ya-ping, Liu Qi, Guo Cheng-wei, Xie Rui-di (Department of Periodontology, Stomatological Hospital Affiliated to Zunyi Medical University, Zunyi 563003, Guizhou Province, China) Abstract BACKGROUND: A series of inflammatory signal pathways are activated accompanied by increasing expressions of inflammatory factors after periodontal tissues being stimulated by exogenous substances like bacterium. Inflammation is closely related to periodontal tissue repair and regeneration. OBJECTIVE: To illustrate the correlation of immune response of periodontitis and periodontitis-related inflammatory cytokines to p38 mitogen activated protein kinase (p38MAPK) pathway, and to provide a new idea and method for the treatment of periodontitis in the future. METHODS: The related literatures of periodontitis and p38MAPK pathway published from January 1990 to January 2016 were retrieved from the databases of CBM, CNKI, SWIC and PubMed. The research and progress of periodontal tissue repair and regeneration after periodontitis were analyzed. RESULTS AND CONCLUSION: Totally 36 literatures were enrolled finally. Inflammation-regulated and inflammation-associated signaling pathways as well as subsequent expression of inflammatory mediators can partly control the excessive disease-induced inflammation and immune responses of the host, among which p38MAPK signaling pathway may be involved in the occurrence and develop