不同干燥工艺对制剂影响的研究进展-天津中草药杂志社.PDF

Drug Evaluation Research 第 35 卷 第 4 期 2012 年 8 月 - 299 - 不同干燥工艺对制剂影响的研究进展 1 2 1 1 * 1 钱丽萍 ，陈雪萍 ，阙慧卿 ，林 绥 ，郭舜民 1. 福建省医学科学研究院，福建省医学测试重点实验室，福建 福州 350001 2. 福建中医药大学，福建 福州 350001 摘 要：干燥工艺在制剂工业上应用十分广泛。不同的干燥工艺对制剂产生的影响各不相同，它不仅会影响制剂的用药量、 临床用药的安全性，还会间接影响到制剂的生产成本。通过介绍干燥及其工艺的基本理论，并结合各种干燥工艺的特点与适 用性，对不同干燥工艺对药物制剂性质和质量的影响、干燥工艺在药物制剂各方面的应用现状和对干燥工艺优化或技术改进 等方面的研究进展进行了综述，为各种干燥工艺的进一步研究、设计、优化和在制剂工业上的推广提供借鉴和帮助。 关键词：干燥工艺；制剂；影响 中图分类号：R943 文献标志码：A 文章编号：1674 - 6376 (2012) 04 - 0299 - 05 Effects of various drying technologies on preparations 1 2 1 1 1 QIAN Li-ping , CHEN Xue-ping , QUE Hui-qing , LIN Sui , GUO Shun-min 1. Fujian Academy of Medical Sciences, Fujian Provincial Key Laboratory of Medical Analysis, Fuzhou 350001, China 2. Fujian University of Traditional Chinese Medicine, Fuzhou 350001, China Abstract: Drying technology is extensively used in preparation industry. Various drying processes have many kinds of effects on preparations. They will not only affect the dosage of preparation and the clinical safety of medication, but also indirectly affect the costs of production. In this paper, the basic theory of drying technology as well as the characteristics and applicability of all kinds of drying technology are introduced. The effects of various drying technologies on the characteristics and quality of preparation, the application status, and the technology optimization or improvements are also reviewed, so as to provide the reference and help for further research, design, and optimization of drying technology in preparation industry. Key words: drying technology; preparation; effects 中药制剂的制备过程包括提取、分离、纯化、 水分不断气化到空中，直至物料中所含水分量达到 浓缩、干燥及成型等工艺。其中，提取、分离和纯 该空气的平衡水分为止。该过程得以进行的必要条 化工艺由于改变了药