茶多酚抗高尿酸血症的研究-core.pdf

351 1,2 1 1 1 1 MA Si-jia DUAN Ling DONG Xin-hai FAN Xing-dan LI Hong-wei 1 2 School of Public Heath, Xiamen University, Xiamen 361102 West China School of Public Health, Sichuan University, Chengdu 610041, China Abstract Objective To observe the effect of tea polyphenols on uric acid level in hyperuricemic rats, and to explore the possible mechanism. Methods Male SD rats were divided into normal control group, hyperuricemic model group and low dose, medium dose, high dose of tea polyphenols groups. The rats of model group and tea polyphenols groups were administered intragastrically with yeast 15g/(kg·d), adenine 200 mg/(kg·d) and Oxonic 30mg/(kg·d) for 30 days to establish the model of hyperuricemia. From the 10th day after modeling, the tea polyphenols groups were treated with 100, 200, 300 mg/(kg·d) of tea polyphenols by oral gavage for 20 days. The model and control groups were continually treated with modeling agent and saline, respectively. At the end of