biomarkers for colorectal cancer生物标志物对结直肠癌.pdf

Int. J. Mol. Sci. 2010, 11, 3209-3225; doi:10.3390/ijm OPEN ACCESS International Journal of Molecular Sciences ISSN 1422-0067 /journal/ijms Review Biomarkers for Colorectal Cancer Takuji Tanaka 1,2,*, Mayu Tanaka 3, Takahiro Tanaka 4 and Rikako Ishigamori 5 1 The Tohkai Cytopathology Institute: Cancer Research and Prevention (TCI-CaRP), 5-1-2 Minami- Uzura, Gifu 500-8285, Japan 2 Department Oncologic Pathology, Kanazawa Medical University, 1-1 daigaku, Uchinada Ishikawa 920-0293, Japan 3 Department of Pharmacy, Kinjo Gakuin University of Pharmacy, Moriyama-Ku, Nagoya, Aichi 463-8521, Japan 4 Department of Physical Therapy, Kansai University of Health Sciences, Kumatori-Machi, Sennan-Gun, Osaka 590-0482, Japan; E-Mail: tmntt08@ 5 Cancer Prevention Basic Research Project, National Cancer Center Research Institute, Tokyo 104-0045, Japan; E-Mail: rishigam@ncc.go.jp * Author to whom correspondence should be addressed; E-Mail: takutt@toukaisaibou.co.jp or takutt@kanazawa-med.ac.jp; Tel.: +81-58-273-4399; Fax: +81-58-273-4392. Received: 18 August 2010; in revised form: 2 September 2010 / Accepted: 3 September 2010 / Published: 13 September 2010 Abstract: Colorectal cancer (CRC) is the third most common epithelial malignancy in the world. Since CRC develops slowly from removable precancerous lesions, detection of the lesion at an early stage by regular health examinations can reduce the incidence and mortality of this malignan