红景天提取物对放疗致小鼠骨髓抑制作用研究.doc

精品论文 参考文献 红景天提取物对放疗致小鼠骨髓抑制作用研究 范文玺 郭小红 刘利 马芹* 　　新疆华世丹药物研究有限责任公司 新疆 乌鲁木齐 830011【摘 要】目的：考察红景天提取物对放疗致小鼠骨髓抑制作用。方法：通过60Cogamma;射线一次性4.0Gy 剂量照射小鼠致骨髓抑制模型，考察红景天提取物对放疗引起的小鼠骨髓抑制的治疗作用。结果：辐射后，小鼠血液中白细胞、血红蛋白、血小板显著降低（与正常组比较Plt;0.01），红细胞明显降低（与正常组比较Plt;0.05），胸腺、脾脏系数显著降低（与正常组比较Plt;0.01），股骨骨髓有核细胞数量明显降低（与正常组比较Plt;0.05），说明放疗致小鼠骨髓抑制模型建立成功。各给药组给药7 天后，红景天提取物各剂量组对白细胞、血红蛋白数量降低具有明显恢复作用（与模型组比较Plt;0.05），能够显著提高血小板的数量（与模型组比较Plt;0.01），能够明显恢复股骨骨髓有核细胞数量（与模型组比较Plt;0.05），对胸腺、脾脏系数降低没有明显作用。结论：说明红景天提取物对60Cogamma;射线一次性4.0Gy 剂量照射致小鼠骨髓抑制具有明显恢复作用。 　　【关键词】红景天；放疗；骨髓抑制Inhibition of bone marrow in mice induced by radiotherapy Rhodiola extractFan Wenxi Guo Xiaohong Liu Li Ma Qin*(Xinjiang huashidan Pharmaceutical Research Co Ltd, Xinjiang, Urumqi, 830011)Abstract Objective: To investigate Rhodiola extract on radiation-induced bone marrow suppression in mice. Methods: Bone marrowsuppression induced by 60Cogamma; ray disposable model 4.0Gy irradiated mice were investigated Rhodiola extract in mice to radiation-inducedbone marrow suppression treatment. Results: After radiation, the mice white blood cells, hemoglobin, platelets decreased significantly(compared with normal group P lt;0.01), red blood cells was significantly decreased (compared with normal group P lt;0.05), thymus, spleenindex decreased significantly (compared with the normal group P lt;0.01), femoral bone marrow nucleated cells was significantly decreased(compared with normal group P lt;0.05), described radiation-induced bone marrow suppression mouse model successfully established. 7 daysafter administration of each dose group, Rhodiola extract each dose group of white blood cells, hemoglobin has significantly reduced thenumber of recovery effect (compared with model group P lt;0.05), can significantly increase the number of platelets (compared with modelgroup P lt; 0.01), on the thymus, spleen and bone marrow of factors have reduced the number of nucleated cells had no effect. Conclusion:Description Rhodiola extract on 60Cogamma; ray irradiation dos