生物安全第三等级试验室安全管理规范-环境保护暨职业安全卫生中心.PDF

“The most effective strategy for the prevention or minimization of laboratory-associated infection is to make certain that approved procedures are consistently carried out.” ___ Harding and Liberman,1995 (Biosafety Level, BSL) (Biosafety Level, BSL) •BSL1 - agents not known to cause disease. •BSL2 - agents associated with human disease. •BSL3 - indigenous/exotic agents associated with human disease and with potential for aerosol transmission. •BSL4 - dangerous/exotic agents of life threatening nature. () () •(organization) •(risk assessment) •(registration and inventory) •(SOP establishment) • (communication) • (control measures) • (monitoring works) () () •(training) • (emergency response procedures) • (medical surveillance) •(documentation) • (shipping and receiving) • (transportation) • (waste management) Risk Assessment Factors -Simulate substitutes -Mode of Transmission -Management -Industry Standards -Communicability -Biosafety and health Professionals -Agent Identity -Mode of Transmission (Known/Unknown) -Communicability