英文会议演讲PPT示例.pptx

Effect of Nesiritide in Patients with Acute Decompensated Heart Failure OConnor CM, Starling RC, Hernandez AF, Armstrong PW, Dickstein K, Hasselblad V, Heizer GM, Komajda M, Massie BM, McMurray JJ, Nieminen MS, Reist CJ, Rouleau JL, Swedberg K, Adams KF Jr, Anker SD, Atar D, Battler A, Botero R, Bohidar NR, Butler J, Clausell N, Corbalán R, Costanzo MR, Dahlstrom U, Deckelbaum LI, Diaz R, Dunlap ME, Ezekowitz JA, Feldman D, Felker GM, Fonarow GC, Gennevois D, Gottlieb SS, Hill JA, Hollander JE, Howlett JG, Hudson MP, Kociol RD, Krum H, Laucevicius A, Levy WC, Méndez GF, Metra M, Mittal S, Oh BH, Pereira NL, Ponikowski P, Tang WH, Tanomsup S, Teerlink JR, Triposkiadis F, Troughton RW, Voors AA, Whellan DJ, Zannad F, Califf RM.Presented by Dr Wang PUMCN Engl J Med. 2011 Jul 7;365(1):32-43 IntroductionTreat acute heart faluireApproved in 2001 by FDAOConnor ,N Engl J Med. 2011 Jul 7;365(1):33 Picture from ControversyOConnor ,N Engl J Med. 2011 Jul 7;365(1):33 Picture from Improvement in heart function and relief in difficult breathingWorsen renal function and increase death rateEffective and safe?Picture from MethodsRandomized, double-blind, placebo-controlled trial From May 2007 through August 2010 at 398 centersWritten informed consentOConnor ,N Engl J Med. 2011 Jul 7;365(1):33 Study patient Key inclusion criteriae.g.,Hospitalized for heart failure within 24 hours Difficult breathing at rest Key exclusion criteriae.g.,High risk of low blood pressureOConnor ,N Engl J Med. 2011 Jul 7;365(1):34End PointsChange in self-reported dyspnea 6 and 24 hours after study-drug initiationRehospitalization for heart failure and death from randomization to day 30OConnor ,N Engl J Med. 2011 Jul 7;365(1):34Statistical analysisEstimated in Cochran–Mantel Haenszel(CMH)testP value ≤0.005OConnor ,N Engl J Med. 2011 Jul 7;365(1):34ResultsOConnor ,N Engl J Med. 2011 Jul 7;365(1):33 Picture from 7141 patients North America, Europe, Latin America, and the Asia–Pacific regionTable 1.C