FKBP12.6对异丙肾上腺素所致心脏肥大和纤维化的影响.pdf

ofAnhui 责任编辑姜丽责任校对张士敏 安徽农业科学。Journal Ash．Sci．2009。37(30)：14720—14724 FKBPl2．6对异丙肾上腺素所致心脏肥大和纤维化的影响 李燕，李小庆，周稚超，蒋维+ (四川大学生物治疗国家重点实验室，华西医院心血管疾病研究室I，四川成都610041) 用，FKBPl2．6可能并不直接影响心肌细胞内质网RyR2的功能。 关键词FKBPl2．6；RYR2；异丙肾上腺素；心肌肥大；心肌纤维化 中图分类号S865．1+3文献标识码A 文章编号0517—6611(2009)30—14720—05 EffectsofFKBPl2．6onCardiac andFibrosisInduced Hypertrophy bylsoproterenol of NationalLaboratoriesfor LIYahetal(TheLaboratoryI CardiovascularDiseases，The Key University，Chengdu，Sichuan610041) 12．6TGmicewas effectsofcardiac andfibrosisinduced used，the hypertrophy by Abstract[Objective]FKBPbindingprotein protection FKBPl2．6 ISOwere and were with over．expresseddiscussed．[Method]TGnon．genetransgenic(NTG)miceinjectedsubcutaneously1SO(5 cardiac andfibrosis．出e ofcardiacfunctionsand structureweremeasuredcardiacultra— hypertrophy changes organization by mg／kg)induced soundand of and tissuesandsoon withthenormalNTG wereno mice，thereany PV—Loopphysiologypathological mean8．[Result]Compared andsizeof inTGmice．AfterISO animalsshowedobvi- differencesinechocardiography。PV—Loop，fibrosiscardiomyocytes administration，all cardiac and Wereno statistical inthe and ously hypertrophyfibrosis．however，themany significancepresented betweenNTGandTG W88no cardiac induced morphologicalparameters mice．[Conclusion]Theresignificantcytoproteetionagainst injury by ISO．TheresultsshowedthatofFKBPl2．6not thefunctionsof