IMMUNOLOGY补体系统课件.ppt

* * * * * * Downloaded from: StudentConsult (on 1 June 2006 02:08 PM) ? 2005 Elsevier 不同途径补体系统激活的比较 经典途径 MBL途径 旁路途径 免疫复合物 病原体甘露糖残基 C1、C4、C2 MASP、C4、C2 病原体表面 C3、B、D C3转化酶 C5转化酶 攻膜复合体 Regulation of complement activation 1.Self-regulation C4b2b C3bBb C4b C3b C5b 2.Control proteins classical pathway:C1INH C4bp I MCP DAF alternative pathway: H I CR1 DAF P formation of MAC: C8bp CD59 complement Downloaded from: StudentConsult (on 1 June 2006 04:16 PM) ? 2005 Elsevier Regulation of complement activation complement C1IHN缺陷引起血管神经性水肿 Regulation of complement activation complement Regulation of complement activation complement Regulation of complement activation complement Regulation of complement activation complement Biological function of complement system 1. complement mediates anti-infection immunity (1) Lysis of cell or microorganisms (2) opsonization (3) inflammation complement Downloaded from: StudentConsult (on 1 June 2006 04:16 PM) ? 2005 Elsevier (1)complement mediated lysis of cells 溶菌 溶细胞 补体的溶细胞作用 (2) opsonization opsonin: C3b, C4b, iC3b cell: phagocyte receptor: CR1, CR3, CR4 function: enhance phagocytosis complement 细菌 C3b受体 吞噬细胞 补体的调理作用 (3) inflammatory response symptoms: redness, swelling, heat and pain inflammation mediators anaphylatoxins: C5a, C3a, C4a chemoattractant: C5a complement 肥大细胞 过敏介质 C5a C3a 补体的过敏毒素作用 C567 C5a C3a 补体的趋化作用 中性粒细胞 单核-巨噬细胞 血管 组织 C1q——识别免疫复合物、识别病毒膜蛋白 C4a——过敏毒素 C4b——组成C3、C5转化酶、参与免疫粘附 C2b——组成C3、C5转化酶 C3a——过敏毒素、趋化因子 C3b——组成C3、C5转化酶、参与免疫粘附、调理作用 C5a——过敏毒素、趋化因子 C5b、C6、C7——趋化因子、组成攻膜复合体 C8、C9——组成攻膜复合体 Ba——参与免疫调节 Bb——组成C3、C5转化酶 补体系统各成分的生物学作用 2. Complement maintains homeostasis clearance of IC (immune complex): C3b elimination of apoptotic cells: C1q, C3b, iC3b 清除免疫复合物 3. Complement mediates adaptive immunity (1) Participates in the induction of immune response (CD19/CD