专着普propranolol hydrochloride tablets4467-盐酸盐片.pdf

USP35OfficialMonographs/Propranolol4467

(3)IfF′isnotbetween0.970and1.030,calculatethedrochloridestocksolutiontoa25-mLvolumetricflask,dilutewith

weightofactiveingredientineachdosageunitbymulti-Mobilephasetovolume,andmix.Thissolutioncontainsabout

plyingeachoftheweightsfoundusingthespecialpro-50µgofhydrochlorothiazideand50Jµgofpropranololhydro-

cedurebyF′.chloridepermL.Usethissolutionwithin3days.

Calculatethequantity,inmg,ofpropranololhydrochlorideAssaypreparation—Carefullyopenanaccuratelycounted

(C16H21NO2·HCl)perCapsulebythesameformula,inwhichCnumberofCapsules,equivalenttoabout500mgofhydrochlo-

istheconcentration,inmgpermL,ofUSPPropranololHydro-rothiazide,andtransferthecontentsandtheCapsuleshellstoa

chlorideRSintheStandardpreparation;AUistheabsorbanceat500-mLvolumetricflask.Add5.0mLofwatertotheflask,and

293nmoftheindividualTestpreparation;andASistheaver-allowtostandfor5minutes.Dilutewithmethanoltovolume,

agedabsorbanceat293nmoftheStandardpreparations.Makemix,andsonicatefor10minutes,addingicetothebath,if

anynecessarycorrectionoftheresultsobtainedasdirectednecessary,tomaintainthetemperatureatnotmorethan20°.

above.Removetheflaskfromthebath,andshakeitoccasionallyfor1

Relatedcompounds—