呼吸系统疾病（三） DISEASES OF RESPIRATORY SYSTEM ….ppt

Cigarette smoking is the main cause of lung carcinoma Heavy cigarette smokers have a 20-fold increases in incidence compared with nonsmokers Cessation of smoking decrease the risk A large number of potent carcinogens are present in cigarette smoke Including polycyclic hydrocarbons, aromatic amines, and heavy metals such as nickel Produce changes in the respiratory: Loss of cilia—squmous metaplasia, dysplasia ,carcinoma in situ, Dysplasia is very uncommon in nonsmokers, Dysplasia ,carcinoma in situ * Industrial carcinogens * * Large cells show no squamous or glandular differentiation. Pleomorphic giant cell, multinucleated giant cells * Pneumonia Chronic Obstructive Passive Diseases Silicosis NPC and Lung cancer Summary Air space pneumonia Lobar pneumonia Lobular pneumonia Interstitial pneumonia Viral pneumonia Mycoplasma pneumonia COPD Silicosis COPD: Chronic bronchitis Asthma Emphysema Bronchiectasis Silicosis Asbestosis Pulmonary hypertension Chronic cor pulmonale NPC Lung carcinoma NPC EBV infection Nasopharygeal roof Non-keratinizing squamous carcinoma Lymphatic route metastasis Lung carcinoma Smoking Hilar, periphera, diffuse type Squamous carcinoma and small cell carcinoma Haematogenous spread Case abstract 1 Male, 70, he had suffered from cough and sputum for 15 years, rapid and short breath after physical labor for 5 years, lower limbs edema repeatedly for 1 year. These symptoms aggravated 4 days ago with fever and purulent sputum. Blood WBC: 10.2 X 109/L X-ray: The lungs are enlarged, Several scattered patchy shadows evidently in bilateral lower lobes. Biopsy: Thinning and destruction of alveolar walls, large airspaces formation. Terminal bronchiole and alveoli are filled with neutrophil. Chronic bronchitisEmphysema Chronic Cor pulmonale Lobular pneumonia COMPLICATED WITH 65, woman, cough with purulent sputum after catching cold 15 years ago. She developed cough and expe