转化生长因子_1基因多态性与结直肠癌相关性的Meta分析.pdf

20 11 8 24 8 J M ed P ostgra, V o. 24, N o. 8, A ugu st, 20 11 # 803# (基础研究) -B1 M eta 李敏惠, 袁 杰, 李 华, 邹 强, 刘 阳, 杨 平 [ ] B 1 ( transform ing grow th factor beta 1, TGF-B 1) -509C /T ( co orecta cancer, CRC ), -B 1-509C /T OR , PubM edCNK ITGF-B 1-509C /T , R evM an 5. 0 , TGF-B 1 -509C /T 10 , 2314 , 4247 , T C TT , , M eta, , , TT ( TC + CC) P = 0. 0 8 0. 05, , , OR 0. 83( 0. 7 ~ 0. 99) , P = 0. 04, ; , , TGF-B 1-509 TT [ ] ; ; -B 1; M eta [ ] R 735. 35 [] A [] 1008-8 199 ( 2011) 08-080 3-05 M eta-analysis of TGF-B1-509C /T gene polym orphism s and colorectal can cer 1 1 4 2 1 3 L IM in-hu i, YUAN Jie , L IH ua , ZOU Q iang , L IU Y ang , YANG P ing ( 1. Scientfi ic Research Center, 2. Departmentof Immunology, 3. D epartment of Biochem istry andM olecular Biology, ChengduM edical College, Chengdu 6 10083, Sichuan, China; 4. D epartment of Oncology, ChengduM ilitary en- eralH osp ita,l Chengdu 610083, Sichuan, China) [ Abstract O bjective In the recent years, m ore and mo re attention is be ing paid to the re a tionsh ip betw een transfo rm ing g row th facto r beta 1 -509C /T ( TG F-B 1-509C /T ) g ene po ym orph ism s and the su sceptibi ity to co orecta cance r ( CRC) . H eterog ene-i ty in genetics and phenotypes ead to different resu ts in d ifferent stud ies. T h is study a mi s to investiga te the re ationship of TGF-B 1- 509C /T g en