综合癌症翻译mri mrsismrm2014.pdf

TranslationalMRI/MRSofCancer

HarishPoptani,PhD

DepartmentofRadiology

UniversityofPennsylvania

Philadelphia,PA,USA

Email:poptanih@uphs.upenn.edu

Highlights:

•TranslationalMRincancerinvolvesstudiesfromthebench-to-bedside.

•MRstudiesofcancercellsaidinunderstandingthemetabolismandenergeticsofcancer.

•Exvivostudiesonextractedtissuesamplesplayapivotalroleinmetabolomics.

•InvivoMRI/MRSstudiesonanimaltumormodelshavehelpedinthedevelopmentof

newcontrastmechanismsaswellasunderstandingoftumorphysiologyandmetabolism.

•Developmentofhighfieldclinicalsandfasterimageacquisitionmethodshave

ledtotranslationofmethodsdevelopedinanimalmodelsintotheclinic.

•Re-designingMRI/MRSmethodsinanimalandmodelsystemstobetterunderstandthe

mechanismoftheobservationsmadeinthecliniccompletesthecircleoftranslational

MRmethodsincancer.

Thisintroductorylectureisgearedtowards“beginner”levelscientists,whoareinterestedin

translationalMRstudiesincancereithergoingfrombench-to-bedside(pre-clinicaltoclinical)or

back.Thepresentationwillprovideanoverviewoftheadvantagesandchal