血清维生素D水平与女童中枢性性早熟的相关性分析.docx

血清维生素D水平与女童中枢性性早熟的相关性分析

娄永峥徐亚男张萍萍潘婕文干冬梅孙淑妮

[关键词]?中枢性性早熟；女童；维生素D

[中图分类号]?R725????[文献标识码]?A????[DOI]?10.3969/j.issn.1673-9701.2024.03.005

Correlation?analysis?between?serum?vitamin?D?level?and?central?precocious?puberty?in?girls

LOU?Yongzheng1，?XU?Yanan2，?ZHANG?Pingping3，?PAN?Jiewen4，?GAN?Dongmei5，?SUN?Shuni6

1.NICU，?Ningbo?Women?and?Children’s?Hospital，?Ningbo?315012，?Zhejiang，?China;?2.Scientific?Research?Department，?Ningbo?Women?and?Children’s?Hospital，?Ningbo?315012，?Zhejiang，?China;?3.Pediatric?Endocrinology?Department，?Ningbo?Women?and?Children’s?Hospital，?Ningbo?315012，?Zhejiang，?China;?4.Central?Laboratory?of?Birth?Defects?Prevention?and?Control，?Ningbo?Women?and?Children’s?Hospital，?Ningbo?315012，?Zhejiang，?China;?5.Emergency?Department，?Ningbo?Women?and?Children’s?Hospital，?Ningbo?315012，?Zhejiang，?China;?6.Pediatric?Cardiology?Department，?Ningbo?Women?and?Children’s?Hospital，?Ningbo?315012，?Zhejiang，?China

[Abstract]?Objective?To?investigate?the?correlation?between?serum?vitamin?D?level?and?central?precocious?puberty?（CPP）?in?girls.?Methods?A?total?of?103?girls?（case?group）?with?central?precocious?puberty?from?Ningbo?Woman?and?Children’s?Hospital?and?53?healthy?girls?（control?group）?from?health?check-ups?in?Ningbo?Women?and?Children’s?Hospital?were?collected?as?subjects.?The?serum?levels?of?25-hydroxyvitamin?D3?[25（OH）D3]?in?the?two?groups?were?detected?by?chemiluminescence?method.?The?weight?and?height?of?girls?in?the?case?group?were?measured.?The?serum?levels?of?follicle-stimulating?hormone?（FSH）?and?its?peak?value，?luteinizing?hormone?（LH）?and?its?peak?value，?estradiol?（E2），?prolactin?（PRL），?human?chorionic?gonadotropin?（HCG）?and?thyroid?function?were?measured?by?radioimmunoassay.?The?peak?value?of?LH/FSH?was?calculated.?B?ultrasound?examination?of?uterine?adnexa?was?completed?to?calculate?uterine?volume?and?bilateral?ovarian?volume.?According?to?the?results?of?serum?25-（OH）D3，?girls?in?the?case?group?were?divided?into?normal?vitamin?D?group?and?vi