B超引导下经腹绒毛与羊膜腔穿刺术在地中海贫血产前诊断中的应用.docx

B超引导下经腹绒毛与羊膜腔穿刺术在地中海贫血产前诊断中的应用

张兰兰黄芬芳龚菲菲蔡海延胡雪梅黄艳华梁佩陈艺娟

[关键词]?地中海贫血；经腹绒毛穿刺术；羊膜腔穿刺术；产前诊断

[中图分类号]?R71????[文献标识码]?A????[DOI]?10.3969/j.issn.1673-9701.2024.03.004

Application?of?B-ultrasound-guided?transabdominal?villus?and?amniocentesis?in?prenatal?diagnosis?of?thalassemia

ZHANG?Lanlan，?HUANG?Fenfang，?GONG?Feifei，?CAI?Haiyan，?HU?Xuemei，?HUANG?Yanhua，?LIANG?Pei，?CHEN?Yijuan

Department?of?Medical?Genetics?and?Prenatal?Diagnosis，?Qinzhou?Maternal?and?Child?Health?Hospital，?Qinzhou?535000，?Guangxi，?China

[Abstract]?Objective?To?explore?the?clinical?application?of?ultrasound-guided?transabdominal?villus?and?amniocentesis?in?the?prenatal?diagnosis?of?thalassemia，?and?to?find?a?suitable?method?for?the?prenatal?diagnosis?of?thalassemia?in?Qinzhou.?Methods?A?total?of?531?high-risk?pregnant?women?with?severe?or?intermediate?thalassemia?during?single?pregnancy?who?were?treated?in?the?Department?of?Medical?Genetics?and?Prenatal?Diagnosis，?Qinzhou?Maternal?and?Child?Health?Hospital?from?March?2021?to?April?2022?were?selected?for?the?study.?According?to?different?sampling?methods，?they?were?divided?into?control?group?（amniocentesis，?n=415）?and?study?group?（transabdominal?villus?puncture，?n=116）.?The?success?rate，?complication?rate?of?the?two?groups?were?compared.?Results?The?success?rate?of?puncture?in?the?control?group?was?100%，?2?cases?were?aborted?within?2?weeks?after?surgery，?17?cases?were?diagnosed?with?severe?alpha-thalassemia，?10?cases?with?severe?β-thalassemia?and?64?cases?with?intermediate?thalassemia，?48?cases?with?moderate?and?severe?thalassemia?induced?labor.?The?success?rate?of?puncture?in?the?research?group?was?100%，?10?cases?were?diagnosed?with?severe?alpha-thalassemia，?4?cases?with?severe?β-thalassemia?and?17?cases?with?intermediate?thalassemia，?and?26?cases?with?moderate?severe?thalassemia?were?induced?labor.?There?was?no?significant?difference?in?puncture?success?rate?and?abortion?rate?between?the?two?methods?（P0.05）.?Conclusion?Both?methods?are?safe?and?eff