肝样胃癌的临床病理特征、预后及研究展望.ppt

我们科室AFPPGC与对照胃癌患者的总生存比较 Is chemotherapy needed in AFPGC at early stage? Recommended! Thank you! * 甲胎蛋白由新生的幼稚肝细胞分泌，胎儿的肝细胞没有发育（分化）完全，分泌的甲胎蛋白量很大，肝癌是尚未分化的肝细胞，当然能大量分泌甲胎蛋白。随着病情恶化它在血清中的含量会急剧增加 * 甲胎蛋白由新生的幼稚肝细胞分泌，胎儿的肝细胞没有发育（分化）完全，分泌的甲胎蛋白量很大，肝癌是尚未分化的肝细胞，当然能大量分泌甲胎蛋白。随着病情恶化它在血清中的含量会急剧增加 The 1-, 3-, and 5-year survival rates of AFP-positive group were 53%,35%, and 28%, respectively. The 1-, 3-, and 5-year survival rates of negative group were 95%, 57%, and 38%, respectively. The AFP-positive group had a significantly poorer survival in comparison to the stage-matched negative group (P0.01; Fig. 3). Significant The significant prognostic factors of the AFP-positive group included: preoperative serum CEA, liver metastasis, operative curability, vascular invasion, serosal invasion, lymph node metastasis, and pathological stage. The 1-, 3-, and 5-year survival rates of AFP-positive group were 53%, 35%, and 28%, respectively. The 1-, 3-, and 5-year survival rates of negative group were 95%, 57%, and 38%, respectively. The AFPpositive group had a significantly poorer survival in comparison to the stage-matched negative group (P0.01; Fig. 3). The significant prognostic factors of the AFP-positive group included: preoperative serum CEA, liver metastasis, operative curability, vascular invasion, serosal invasion, lymph node metastasis, and pathological stage (Table III). The independent prognostic factors included: liver metastasis and pathological stage (Table IV; Fig. 4). The 1-, 3-, and 5-year survival rates of AFPPGC were 64%, 47%, 41%, respectively. The 1-, 3-, and 5-year survival rates HAS were 30%, 13%, and 9%, respectively. The 1-, 3-, and 5-year survival rates of CGC were 95%, 57%, 38%, respectively. These differences were statistically significant among three groups (P 0.01; Fig. 3). * AFP 甲种胎儿球蛋白，甲型胎儿蛋白糖蛋白 正常情况下，来自胚胎的肝细胞和卵黄囊。 胎儿出生约两周后甲胎蛋白从血液中消失。 正常人血清中甲胎蛋白的含量尚不到20微克／升。 新生幼稚肝细胞 （未分化完全） 分泌AFP量很大 肝癌细胞 （尚未分化的肝细胞） 8