2023 PDS共识：氨甲环酸治疗黄褐斑的处方实践.docx

Abstract

Abstract

Introduction:ThereisambiguityregardingusageoftranexamicacidformelasmainIndia,beitinitspre-administrationevaluation,ad-ministrationroute,dosingormonitoring.Hence,weconductedthisstudytounderstandvarioustranexamic-acidprescribingpaternsandprovidepracticalguidelines.

Materialsandmethods:AGoogle-form-basedquestionnaire(25-questions)waspreparedbasedonthekeyareasidentifedbyexpertsfromthePigmentaryDisordersSociety,Indiaandcirculatedtopracticingdermatologistsacrossthecountry.Inrounds2and3,thequestion-nairewasre-presentedtothesamegroupofexpertsandtheiropinionsweresought.Theresultsofthepractitioners’surveyweredenotedgraphicalyalongside,toguidethem.Consensuswasdeemedwhenatleast80%ofrespondentschoseanoption.

Results:Themembersagreedthathistorypertainingtoriskfactorsforthromboembolism,cardiovascularandmenstrualdisordersshouldbesoughtinpatientsbeingstartedonoraltranexamic-acid.Baselinecoagulationprofleshouldbeorderedinalpatientspriortotranexamic-acidandmoreexhaustiveinvestigationssuchascompletebloodcount,liverfunctiontest,proteinCandSinpatientswithhighriskofthromboembolism.Thepreferredoraldosewas250mgoralytwicedaily,whichcanbeusedaloneorincombinationwithtopicalhydroquinone,kojicacidandsunscreen.Repeateddosingoftranexamic-acidmayberequiredforthoserelapsingwithmelasmafolowinginitialtranexamic-aciddiscontinuation.Coagulationprofleshouldidealyberepeatedatthreemonthlyintervalsduringfolow-up,especialyinpatientswithclinicalyhigherriskofthromboembolism.Treatmentcanbestoppedabruptlypostimprovementandnotaperingisrequired.

Limitation:Thisstudyislimitedbythefactthatopen-endedquestionswerelimitedtothefrstgeneralsurveyround.

Conclusion:Oraltranexamic-acidprovidesavaluabletreatmentoptionformelasma.Frequentcoursesoftherapymayberequiredto