PI3K_AKT通路在非小细胞肺癌顺铂耐药中的作用_张雨.pdf

中国肺癌杂志2014年8月第15卷第8期 Chin J Lung Cancer, August 2014, Vol.15, No.8 ·635· DOI: 10.3779/j.issn.1009-3419.2014.08.09 · 综 述 · PI3K/AKT通路 在非小细胞肺癌顺铂耐药中的作用 张雨 陆红玲 徐刚 【摘要】 研究表明，PI3K/AKT信号通路在非小细胞肺癌存在异常激活，对肿瘤细胞的增殖、凋亡、存活、 耐药等起着重要的作用。顺铂是临床最常用一线化疗药物，但随着治疗的进展肿瘤对其耐药的现象越来越普遍，严 重制约其临床效果。顺铂耐药是多种机制共同参与的复杂过程，其中PI3K/AKT通路或其组分持续被激活是非常重 要的因素之一。本文对二者关系研究领域的进展作一综述。 【关键词】 肺肿瘤；PI3K/Akt通路；顺铂；耐药；分子机制 Effect of PI3K/AKT Pathway on Cisplatin Resistance in Non-small Cell Lung Cancer Yu ZHANG1, Hongling LU2, Gang XU1 1Departmen of Cardiothoracic Surgery, Affiliated Hospital of Zunyi Medical College, Zunyi 563099, China; 2Department of Biochemistry, Zunyi Medical College, Zunyi 563099, China Corresponding author: Gang XU, E-mail: xglhl333@163.com 【Abstract】 Accumulating evidences indicate that aberrant activation of PI3K/AKT pathway in non-small cell lung cancer plays a vital role in tumor cell proliferation,apoptosis, and survival including drug resistance. Cisplatin as first-line che- motherapy are in widespread clinical use in patients with non-small cell lung cancer, however, the development of cisplatin resistance significantly impedes its clinic efficacy. Cisplatin resistance is a complicated process that various mechanisms par- ticipating in to interact, of which PI3K/AKT pathway keeping sustained activated is one of the most important reasons. This article reviewed the progress of research on the relationship between PI3K/AKT pathway and cisplatin resistance. 【Key words】 Lung neoplasms; PI3k/AKT p