cooperation between engulfment receptors the case of abca1 and megf10合作吞没受体abca1和megf10.pdf

Cooperation between Engulfment Receptors: The Case of ABCA1 and MEGF10 1 1 2 3 1 4 3 1 Yannick Hamon , Doriane Trompier , Zhong Ma , Victor Venegas , Matthieu Pophillat , Vincent Mignotte , Zheng Zhou , Giovanna Chimini * ´ ´ 1 Centre d’Immunologie de Marseille Luminy, Institut National de la Sante et de la Recherche Medicale, Centre National de la Recherche Scientifique, ´ ´ ´ Universite de la Mediterranee, Marseille, France, 2 Carter Immunology Center and the Department Of Microbiology, University of Virginia, Charlottesville, Virginia, United States of America, 3 Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of ´ ´ Medicine, Houston, Texas, United States of America, 4 Institut Cochin, Institut National de la Sante et de la Recherche Medicale U 567, Centre National ´ de la Recherche Scientifique UMR 8104, Universite Paris V, Paris, France The engulfment of dying cells is a specialized form of phagocytosis that is extremely conserved across evolution. In the worm, it is genetically controlled by two parallel pathways, which are only partially reconstituted in mammals. We focused on the recapitulation of the CED-1 defined pathway in mammalian systems. We first explored and validated MEGF10, a novel receptor bearing striking structural similarities to CED-1, as a bona fide functional ortholog in mammals and hence progressed toward the analysis of molecular interactions alon