controlled release of diclofenac from matrix polymer of chitosan and oxidized konjac glucomannan双氯芬酸从母体聚合物壳聚糖控释和氧化魔芋葡甘露聚糖.pdf

Mar. Drugs 2011, 9, 1649-1663; doi:10.3390/md9091649 OPEN ACCESS Marine Drugs ISSN 1660-3397 /journal/marinedrugs Article Controlled Release of Diclofenac from Matrix Polymer of Chitosan and Oxidized Konjac Glucomannan Suphat Korkiatithaweechai, Pornpusadee Umsarika, Narong Praphairaksit and Nongnuj Muangsin * Department of Chemistry, Faculty of Science, Chulalongkorn University, 254 Phayathai Road, Bangkok 10330, Thailand; E-Mails: suphat.top@ (S.K.); jp_pu_24@ (P.U.); narong.pr@chula.ac.th (N.P.) * Author to whom correspondence should be addressed; E-Mail: nongnuj.j@chula.ac.th; Tel./Fax: +662-218-7635. Received: 2 August 2011; in revised form: 6 September 2011 / Accepted: 9 September 2011 / Published: 23 September 2011 Abstract: The controlled release of diclofenac sodium (DFNa) from a chitosan-oxidized konjac glucomannan (CTS-OKG) polymer film was studied. Konjac glucomannan (KGM) was initially oxidized by sodium periodate and then cross-linked to CTS via imine bonds (–C=N–) to form the new CTS-OKG copolymer. The DFNa loaded CTS-OKG polymers were characterized by Fourier transformed infrared spectroscopy (FT-IR) and X-ray diffractometry (XRD). Finally, the release profiles of DFNa from the CTS-OKG polymer matrices were evaluated in a simulated gastrointestinal fluid system comprised of two hours in simulated gastric fluid (SGF; pH 1.2) followed by 24 h in simulated intestinal fluid (SIF; pH 7.4). A 1:2:1 (w/w/w) ratio of CTS:OKG:DFNa prepared at r