combinational spinal gad65 gene delivery and systemic gaba-mimetic treatment for modulation of spasticity组合脊髓gad65基因传递和系统性gaba-mimetic治疗痉挛状态的调制.pdf

Combinational Spinal GAD65 Gene Delivery and Systemic GABA-Mimetic Treatment for Modulation of Spasticity 1 1 2 1 1 Osamu Kakinohana , Michael P. Hefferan , Atsushi Miyanohara , Tetsuya Nejime , Silvia Marsala , 3 3 3 4 3 1 Stefan Juhas , Jana Juhasova , Jan Motlik , Karolina Kucharova , Jan Strnadel , Oleksandr Platoshyn , 5 6,7 8 1,6 Peter Lazar , Jan Galik , Laurent Vinay , Martin Marsala * 1 Neuroregeneration Laboratory, Department of Anesthesiology, University of California San Diego, La Jolla, California, United States of America, 2 Gene Therapy Program and Department of Pediatrics, University of California San Diego, La Jolla, California, United States of America, 3 Institute of Animal Physiology and Genetics, AS CR, ˇ Libechov, Czech Republic, 4 Sanford-Burnham Medical Research Institute, La Jolla, California, United States of America, 5 Department of Breeding and Diseases of Game ˇ ˇ and Fish, University of Veterinary Medicine and Pharmacy, Komenskeho, Kosice, Slovakia, 6 Institute of Neurobiology, Slovak Academy of Sciences, Kosice, Slovakia, ˇ ´ ´ 7 Faculty of Science, Institute of Biology and Ecology, Pavol Jozef Safarik Univer