21例骨瓜提取物致不良反应文献分析_易丹.pdf

10 3 2013 3 March, 2013, Vol.10, No.3 中国药物警戒第 卷第 期 年 月 R286; R994.11 A 1672- 8629 2013 03- 0175- 03 中图分类号： 文献标识码： 文章编号： （ ） 21 例骨瓜提取物致不良反应文献分析 412000 易丹 罗晓波 陆向红（株洲市一医院药剂科，湖南株洲 ） 摘要：目的探讨骨瓜提取物致不良反应的特点及相关因素，为临床合理用药提供参考。方法检索 1994 年～2012年 国内医药期刊报道的骨瓜提取物所致不良反应案例，并进行统计、分析。 骨瓜提取物致不良反应在高年龄组发 结果 30 min - 生率较高，多在用药过程中 内发生。不良反应累及多个系统 器官，临床表现复杂多样，主要表现为变态反 应，严重者可出现呼吸困难或过敏性休克。结论临床医师、药师应重视骨瓜提取物的不良反应，坚持合理用药。 骨瓜提取物；药品不良反应；文献；分析 关键词： Literature Analysis of 21 Cases of Adverse Drug Reactions Induced by Extraction of Bone- melon YI Dan LUO Xiao-bo LU Xiang-hong (The First Hospital of Zhuzhou; Hunan Zhuzhou 412000, China) Abstract Objective ： To explore the characteristics and related factors of adverse drug reactions(ADR) induced by extraction of bone-melon so as to provide references for rational clinical drug use. Methods ADR cases induced by extraction of bone-melon reported in domestic medical journals during 1994 ～2012 were collected and analyzed statistically. Restuls ADR induced by Extraction of Bone-melon often occurred in aged group. The onset of ADR was usually within 30min after injection. ADR could involve multiple organs and systems, and clinical manifestations were various, mainly allergic reactions. Severe allergic reactions could manifest dyspneic respiration and anaphylactic shock. Conclusion Clinical physicians and pharmacist should pay attention to the ADR induced by extraction of bone-melon and persist in rational drug use. Key words: extraction of bone-melon; adver