contributions of dopamine-related genes and environmental factors to highly sensitive personality a multi-step neuronal system-level approach贡献的多巴胺基因和环境因素高度敏感的个性一个多步骤的神经系统级的方法.pdf

Contributions of Dopamine-Related Genes and Environmental Factors to Highly Sensitive Personality: A Multi-Step Neuronal System-Level Approach 1 2 3 4 5 6 1 1 Chunhui Chen , Chuansheng Chen , Robert Moyzis , Hal Stern , Qinghua He , He Li , Jin Li , Bi Zhu , Qi Dong1* 1 State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China, 2 Department of Psychology and Social Behavior, University of California Irvine, Irvine, California, United States of America, 3 Department of Biological Chemistry and Institute of Genomics and Bioinformatics, University of California Irvine, Irvine, California, United States of America, 4 Department of Statistics, University of California Irvine, Irvine, California, United States of America, 5 Brain and Creativity Institute, University of Southern California, Los Angeles, California, United States of America, 6 Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China Abstract Traditional behavioral genetic studies (e.g., twin, adoption studies) have shown that human personality has moderate to high heritability, but recent molecular behavioral genetic studies have failed to identify quantitative trait loci (QTL) with consistent effects. The current study adopted a multi-step approach (ANOVA followed by multiple regression and permutation) to assess the cumulative effects of multiple QTLs. Using a system-level (dopamine system) genetic approach, we investigated a personality trait deeply rooted in the nervous system (the Highly Sensitive Personality, HSP). 480 healthy Chinese college students were given the HSP scale and genotyped for 98 representative polymorphisms in all