刺激中缝背核调制小脑间位核神经元电活动(英文).pdf

维普资讯 动 物 学 研 究 1996，17(4)：393--4．01 CN 53—1040／Q ISSN 0254—5853 ZoologicalResearch M 0DULAT10N 0F NEUR0NAL ACTIVITY 0F CEREBELLAR INTERPoSED NUCLEUS BY STIM ULATING D0RSAL RAPHE NUCLEUS IN TH E RAT WangJianjun Cher~Wenyan Zhang M inyue YuQ ixiang (DepartmentofBiologicalScienceandTechnology gUniversity．Nan]ng．China210093) Abstract TheeffectsofstimulatingdorsaIraphenucleus(DR)onactivityofcerebeliar interposed nucleus(1N)wasinvestigated StimulationofDR elicited inhibitory．excitatory andbiphasic(inhibition—excitationandexCitation—inhibition)reSpOnesSfrom IN cells．Th e n~jorityofresponsivecellsshowedaninhibitory respoiks~(76．O％)withalatencyoflessthan 30ms．Thespontaneousdischargerfequenciesofthe IN ~xllswere 5to 120Hz．and theIN cellswithhigherdischargefrequenciesshowed low responsiveratestotheDR stimulation in comparisonwiththoseIowerfiringfrequnecycellsInjectionof5一HT2／1Creceptorantago- nistmethyesrgidc(iv)couldblockthedepressiveeffectofDR stimulationO111theIN cells (85．7％)Theseresultssuggestthatraphe-cerebellarserotonergicafferentfibersmaybein· volvedin thecerebeUaresnsorimotorintegrationprocessby exertingtheirm odulatory action 0nhtedeepcerebeHarnuclearce llsactivities Keywords Dorsalraphenucleus，Cerebellarinterposednucleus，Ra口he—cerebellarprojection， Serotne ergicfibers M anyhistologicalstudieshaved