脑心通论文：脑心通中成药冠状动脉血栓形成血小板聚集抑制剂炎症趋化因子类动物实验大鼠.doc

脑心通论文：脑心通胶囊联合双联抗血小板疗法防治大鼠自体微血栓所致冠状动脉微栓塞 【中文摘要】:探讨脑心通胶囊(Naoxintong capsule, NXT)联合双联抗血小板疗法(dual antiplatelet therapy, DA )对大鼠自体冠状动脉微栓塞( coronary microembolization, CME)的治疗效果。方法:在夹闭升主动脉的同时自心尖部注入同源大鼠微血栓(大鼠自体血凝块经38μm的滤网过滤制成)建立CME模型。95只大鼠不均等随机分成6组,即空白组(n =10)、假手术组(n =10)、CME组(n =15)、NXT组(n =15)、DA组(n =30)、NXT联合DA组(NDA组,n =15)。各组术前预给药3 d,术后继续用药7 d,取血后处死动物收集标本。共计69只大鼠获得完整数据。苏木精-伊红染色观察CME数量百分比(CME%),剪尾法检测出血时间(bleeding time, BT),玻片法检测凝血时间(clotting time, CT),比浊法检测二磷酸腺苷诱导的最大血小板聚集率(platelet aggregation rate, PAR),自动血液分析仪检测血小板计数,酶联免疫吸附试验法检测P选择素、白细胞介素6... 【英文摘要】:In the present study, the efficacy of Naoxintong capsule (NXT), a compound Chinese herbal medicine, combined with dual antiplatelet therapy (DA) in a rat model of coronary microembolization (CME) was evaluated.Methods:CME in rats was developed by injecting a suspension of microthrombotic particles into the left ventricle when the ascending aorta was obstructed. Microthrombotic particles were generated from the clots of rats sized by filtration through a screen (aperture diameter, 38μm)... 【关键词】脑心通 中成药 冠状动脉血栓形成 血小板聚集抑制剂 炎症趋化因子类 动物实验 大鼠 【英文关键词】Naoxintong Chinese patent drugs coronary thrombosis platelet aggregation inhibitors chemokines animal experimentation rat 【索购全文】联系Q1：138113721 Q2：139938848 【目录】脑心通胶囊联合双联抗血小板疗法防治大鼠自体微血栓所致冠状动脉微栓塞 缩略词表 4-5 中文摘要 5-7 Abstract 7-8 前言 9-11 材料与方法 11-23 结果 23-29 讨论 29-36 结论 36-37 参考文献 37-45 综述 45-52 参考文献 49-52 致谢 52