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View Article Online / Journal Homepage / Table of Contents for this issue TUTORIAL REVIEW /csr | Chemical Society Reviews Fluorescent core–shell silica nanoparticles: towards ‘‘Lab on a Particle’’ architectures for nanobiotechnology Andrew Burns,a Hooisweng Owb and Ulrich Wiesner*a Received 31st July 2006 First published as an Advance Article on the web 15th September 2006 DOI: 10.1039/b600562b Novel nanoscale fluorescent materials are integral to the progress of emergent fields such as nanobiotechnology and facilitate new research in a variety of contexts. Sol–gel derived silica is an B 2 excellent host material for creating fluorescent nanoparticles by the inclusion of covalently-bound 6 5 0 organic dyes. Significant enhancements in the brightness and stability of organic dye emission can 0 6 3 B be achieved for silica-based core–shell nanoparticle architectures at length scales down to tens of 1 / 0 9 2 3 h 0 nanometers with narrow size distributions. This tutorial review will highlight these findings and c 1 r . a 0 describe the evolution of the fluorescent core–shell silica nanoparticle concept towards integration 1 M : i 7 o of multiple functionalities including mesoporosity, metal nanoshells and quantitative chemical 2 d | n g sensing. These developments point towards the development of ‘‘lab on a particle’’ architectures o r o N c. with promising prospects for nanobiotechnology, drug development and beyond. E s r G . N s b I u B p particle size distributions suited for applications in the life E / Introduction