基因毒性杂质之结构警示（欧洲）.pdf

Development of structural alerts for the in vivo micronucleus assay in rodents a a a Romualdo Benigni , Cecilia Bossa , Olga Tcheremenskaia and Andrew Worthb a Istituto Superiore di Sanita’, Environment and Health Department, Rome, Italy b Institute for Health Consumer Protection, European Commission - Joint Research Centre, Ispra, Italy EUR 23844 EN - 2009 The mission of the IHCP is to provide scientific support to the development and implementation of EU policies related to health and consumer protection. The IHCP carries out research to improve the understanding of potential health risks posed by chemical, physical and biological agents from various sources to which consumers are exposed. European Commission Joint Research Centre Institute for Health and Consumer Protection Contact information Address: TP 582 E-mail: andrew.worth@ec.europa.eu Tel.: +39 0332 789566 Fax: +39 0332 786717 http:// http://ecb.jrc.ec.europa.eu/qsar/ http://ec.europa.eu/dgs/jrc/ Legal Notice Neither the European Commission nor any person acting on behalf of the Commission is responsible for the use which might be made of this publication. A great deal of additional information on the European Union is available on the Internet. It can be accessed through the Europa server http://europa.eu/ JRC 52274 EUR 23844 EN ISSN 1018-5593 Luxembourg: Office for Official Publications of the European Communities © European Communities, 2009 Reproduction is authorised provided the source is acknowledged Printed in Italy ABSTRACT In vivo mutagenicity and carcinogenicity studies are posing a high demand for test- related resources. Among these studies,