biodegradability of poly(hydroxyalkanoate) materials保利(hydroxyalkanoate)材料的生物降解性.pdf

Materials 2009, 2, 1104-1126; doi:10.3390/ma2031104 OPEN ACCESS materials ISSN 1996-1944 /journal/materials Review Biodegradability of Poly(hydroxyalkanoate) Materials Keiji Numata 1,2, Hideki Abe 2 and Tadahisa Iwata 2,3,* 1 Department of Biomedical Engineering, Tufts University / 4 Colby Street, Medford, MA 02155, USA; E-Mail: keiji.numata@ (K.N.) 2 Chemical Analysis Team, RIKEN Advanced Science Institute/ Hirosawa 2-1, Wako-shi, Saitama 351-0198, Japan; E-Mail: habe@riken.jp (H.A.) 3 Department of Biomaterial Sciences, Graduate School of Agricultural and Life Sciences, The University of Tokyo / 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan * Author to whom correspondence should be addressed; E-Mail: atiwata@mail.ecc.u-tokyo.ac.jp; Tel. +81-3-5841-7888; Fax: +81-3-5841-1304. Received: 15 July 2009; in revised form: 19 August 2009 / Accepted: 24 August 2009 / Published: 28 August 2009 Abstract: Poly(hydroxyalkanoate) (PHA), which is produced from renewable carbon resources by many microorganisms, is an environmentally compatible polymeric material and can be processed into films and fibers. Biodegradation of PHA material occurs due to the action of extracellular PHA depolymerase secreted from microorganisms in various natural environments. A key step in determining the overall enzymatic or environmental degradation rate of PHA material is the degradation of PHA lamellar crystals in materials; hence, the degradation mechanism of PHA lamellar crystals