targeting cell signaling and apoptotic pathways by luteolin cardioprotective role in rat cardiomyocytes following ischemiareperfusion针对细胞信号和凋亡通路由毛地黄黄酮在大鼠心血管作用ischemiareperfusion后心肌细胞.pdf

Nutrients 2012, 4, 2008-2019; doi:10.3390/nu4122008 OPEN ACCESS nutrients ISSN 2072-6643 /journal/nutrients Review Targeting Cell Signaling and Apoptotic Pathways by Luteolin: Cardioprotective Role in Rat Cardiomyocytes Following Ischemia/Reperfusion Tongda Xu 1,2, Dongye Li 1,2,* and Dehua Jiang 2 1 The First Clinical College, Nanjing Traditional Chinese Medicine University, Nanjing, Jiangsu 210046, China; E-Mail: xtd3004@ 2 Research Institute of Cardiovascular Diseases, Xuzhou Medical College, Xuzhou, Jiangsu 221002, China; E-Mail: yiyuanerzhu1021@163.com * Author to whom correspondence should be addressed; E-Mail: ldy@; Tel.: +86-0516-8558-2763; Fax: +86-0516-8558-2753. Received: 31 October 2012; in revised form: 28 November 2012 / Accepted: 5 December 2012 / Published: 12 December 2012 Abstract: Myocardial ischemia often results in damaged heart structure and function, which can be restored through ischemia/reperfusion (I/R) in most cases. However, I/R can exacerbate myocardial ischemia reperfusion injury (IRI). Luteolin, a widely distributed flavonoid, a member of a group of naturally occurring polyphenolic compounds found in many fruits, vegetables and medicinal herbs, has been reported to exhibit anti-inflammatory, antioxidant and anti-carcinogenic activities. In recent years, luteolin has been shown to play an important role in the cardioprotection of IRI. However, its role and mechanism in cardioprotection against IRI has not been clearly elucidated with res