一氧化氮与一氧化氮合酶在水生动物免疫系统中的研究进展.pdf

水水产科水产科产科技技技 FISHERIEFISHERIEFISHERIESSS SCIENCSCIENCSCIENCEEE ＆＆＆ TECHNOLOGYTECHNOLOGYTECHNOLOGY 1 一氧化氮及一氧化氮合酶 在水生动物免疫系统中的 研究进展 王广军 谢骏 余德光 郁二蒙 王海英 龚望宝 朱宏友 （中国水产科学研究院珠江水产研究所 广州 510380） 摘要 一氧化氮作为一种新型生物信使分子、效应分子和免疫调节分子，广泛分布于生物体的各个器 ： 官和组织中，参与机体多种重要的生理病理活动，可以通过非特异性地杀伤细菌、真菌、寄生虫及病毒等， 增强机体的非特异性免疫，因此成为近几年生命科学领域研究的热点。本文综述了一氧化氮及一氧化氮合 酶的研究概况，以及在鱼、虾、贝等免疫方面的研究进展，并探讨了其在水产养殖中的应用前景。 关键词 一氧化氮，一氧化氮合酶，免疫系统，水生动物 ： The advances of the nitric oxide and nitric oxide synthase in immune system of aquatic animals WANG Guang-jun, XIE Jun, YU De-guang, YU Er-meng, WANG Hai-ying, GONG Wang-bao, ZHU Hong-you (Pearl River Fishery Research Institute, Chinese Academic of Fishery Science, Guangzhou 510380) Abstract The nitric oxide(NO), which produced during the conversion of L-arginine to L-citrulline by NO synthase (NOS), is a free radical biological messenger with numerous function, including regulation of vascular tone, cellular signaling, is ubiquitous in all living organs and tissues. It takes part in many important physiolog － ical and pathological reactions, and can kill the bacteria, fungi, parasite or virus non- specifically with improv － ing the non-specific immune function. In recent years, studies on NO have been gotten on very quickly in the life science field. In this paper, the summary of NO/NOS, and the advances of NO/NOS in immune system of fish, shrimp and shellfish were summarized. At the same time, the application perspectives of NO/NOS in aqua － culture were discussed. Key words Nitric oxide; Nitric oxide synthase; Immune system; Aquatic animals 综述