酒精性肝硬化与Hp感染相关性Meta分析.doc

酒精性肝硬化与Hp感染相关性的Meta分析 冯灏1 , 周晓颖2，殷杰1 ，袁斐1 ，陈泉1 1 南京江北人民医院感染科 南京市葛关路552号 210048 2 南京医科大学第一附属医院，江苏省人民医院消化科 南京市广州路300号210029 【摘要】目的 酒精性肝硬化严重威胁着公众健康。近年来有研究表明酒精性肝硬化可能与幽螺旋杆菌（Helicobacter pylori，Hp）感染相关，但其相关性尚未明确，本文旨在揭示两者间的关系并评价其相关性。方法 收集所有已发表的有关酒精性肝硬化患者H. Pylori发病率的文献，记录发表年份、地区、第一作者、研究人群及检测方法等数据，建立Meta回归模型并同时进行亚组分析及异质性检测。结果 一共搜索318篇文献，8篇符合入选标准。所有入选文献共纳入人数14226名，总的HP感染率为70.67%。本Meta分析结果揭示酒精性肝硬化患者及对照组之间HP 感染率无明显差异(odd ratio (OR) =0.82, 95% confidence interval (CI): 0.35-1.91, p0.0001)。亚组分析提示欧洲人群中酒精性肝硬化患者的HP感染率明显高于对照组，而亚洲人群则无明显差异。结论 统计结果表明仅欧洲人群中酒精性肝硬化患者的HP感染率明显高于对照组。为进一步揭示酒精性肝硬化与HP感染的关系，需要进行深入的大范围、多中心的调查研究。 【关键词】 幽门螺旋杆菌；酒精性肝硬化； Meta分析 Alcoholic cirrhosis and Hp infection in Meta-analysis Hao Feng1 , Xioayin Zhou2，Jie Yin1 ，Fei Yuan1 ，Quan Chen1 1 Department of Infectious Diseases, Nanjing Jiangbei People’s Hospital, No.552 Geguan Road, Nanjing 210048, China 2 Department of Gastroenterology, First Affiliated Hospital of Nanjing Medical University, First Clinical Medical College of Nanjing Medical University, No. 300 Guangzhou Road，Nanjing 210029, China 【Abstract】Objective Alcoholic cirrhosis is a severe threat to public health. Some studies have suggested that alcoholic cirrhosis have a relationship to Helicobacter pylori(H. Pylori) infection, but the relation remains controversial. This meta-analysis was conducted to quantify the association between alcoholic cirrhosis and H. Pylori infection. Methods Published information on H. Pylori prevalence in patients with alcoholic cirrhosis was collected to assess the potential associations between H. Pylori infection and alcoholic cirrhosis risk. Eight eligible studies were included for analysis. Data on the publication year, detection method, and study populations were summarized. Meta-regression models and subgroup analyses were established to screen the factors resulting heterogeneity. Results Of the 318 articles retrieved, 8 met the inclusion criteria. These studies involved 14226 cases, with a total H. Pylori infection r