ω-conotoxin gvia mimetics that bind and inhibit neuronal cav2.2 ion channelsω-conotoxin gvia模拟结合,抑制神经元cav2.2离子通道.pdf

Mar. Drugs 2012, 10, 2349-2368; doi:10.3390/m OPEN ACCESS Marine Drugs ISSN 1660-3397 /journal/marinedrugs Article ω-Conotoxin GVIA Mimetics that Bind and Inhibit Neuronal Ca 2.2 Ion Channels v Charlotte Elisabet Tranberg 1,†, Aijun Yang 2, Irina Vetter 2, Jeffrey R. McArthur 3, Jonathan B. Baell 4, Richard J. Lewis 2, Kellie L. Tuck 5,* and Peter J. Duggan 1,* 1 CSIRO Materials Science and Engineering, Bag 10, Clayton South, Victoria 3169, Australia; E-Mail: l.tranberg@.au 2 Institute for Molecular Bioscience, The University of Queensland, St Lucia, QLD 4072, Australia; E-Mails: aijun.yang@csiro.au (A.Y.); i.vetter@.au (I.V.); r.lewis@.au (R.J.L.) 3 Health Innovations Research Institute, RMIT University, Melbourne, Victoria 3083, Australia; E-Mail: jeffrey.mcarthur@.au 4 Medicinal Chemistry and Drug Action, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, Victoria 3052, Australia; E-Mail: Jonathan.Baell@ 5 School of Chemistry, Monash University, Clayton, Victoria 3800, Australia † Current address: Faculty of Science and Technology, Deakin University, Locked Bag 20000, Geelong, Victoria 3220, Australia. * Authors to whom correspondence should be addressed; E-Mails: peter.duggan@csiro.au (P.J.D.); kellie.tuck@ (K.L.T.); Tel.: +61-3-9545-2560 (P.J.D.); +61-3-9905-4510 (K.L.T.); Fax: +61-3-9545-2446 (P.J.D.); +61-3-9905-4597 (K.L.T.). Received: 12 September 2012; in revised form: 10 October 2012 / Accepted: 12 October 2012 / Published: 22 October 2012 Abstract: The neuronal voltage-