birth size and breast cancer risk re-analysis of individual participant data from 32 studies出生大小和乳腺癌风险有关的个人数据来自32个研究参与者.pdf

PLoS MEDICINE Birth Size and Breast Cancer Risk: Re-analysis of Individual Participant Data from 32 Studies [* [ Isabel dos Santos Silva , Bianca De Stavola , Valerie McCormack, Collaborative Group on Pre-Natal Risk Factors and Subsequent Risk of Breast Cancer Department of Epidemiology and Population Health, London School of Hygiene Tropical Medicine, London, United Kingdom Funding: Funding was obtained A B S T R A C T from Cancer Research UK (CR-UK) programme grant (C150/A5660) to IdSS. CR-UK Training Fellowship (C14292/A5609) to VM. The funder Background had no role in study design, data collection and analysis, decision to Birth size, perhaps a proxy for prenatal environment, might be a correlate of subsequent publish, or preparation of the breast cancer risk, but findings from epidemiological studies have been inconsistent. We re- manuscript. analysed individual participant data from published and unpublished studies to obtain more Competing Interests: See section at precise estimates of the magnitude and shape of the birth size–breast cancer association. end of manuscript. Academic Editor: Hans-Olov Adami, Methods and Findings Institutionen for Medicinsk Epidemiologi och Biostatistik (MEB), Studies were identified through computer-assisted and manual searches, and personal Sweden communication with investigators. Individual participant data from 32 studies, comprising Citation: dos Santos Silva I, De 22,058 breast cancer cases, were obtained. Random effect models were used, if appropriate, to Stavo