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氟西汀对野百合碱诱导肺动脉高压大鼠肺动脉尾加压素ⅱ表达的影响分析.pdf

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Effectof onthe of fluoxetine expression urotensinⅡin inrats pulmonaryartery withmonocrotaline--induced pulmonaryhypertension Introduction from Bernin Urotensin mirabilis 1985, 1I,separatedgilliehthysby isasomatostatin--likeandisthemost vasoconstric~ neuropeptide potent toridentifiedSOfar.Anovel orphanG—protein—coupledreceptor GPRl4isthe ofurotensin itsre— specialreceptor II.BothurotensinⅡand inthe of are cardiovascularmammali— eeptorexpressedabundantly system ananimalsandhuman.urotensinIIcanconstrictmain arteries pulmonary inrats.Furthermore,theEmaxwasenhancedinvesselsremovedfrom rats tochronic lIcanalsoinduce exposed hypoxia.urotensin proliferation of smoothmusclecells.In bloodflow—induced vessels highpulmonary andchronic modelsofrats, hypoxia—inducedpulmonaryhypertension the of themiddleandsmall arteries urotensinⅡin expression pulmonary is withcontrol indicates highcompared group,whichurotensinⅡcan contributetOthe of pathogenesispulmonary (MCT)——induced modelis hypertensio
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