氟西汀对野百合碱诱导肺动脉高压大鼠肺动脉尾加压素ⅱ表达的影响分析.pdf
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Effectof onthe of
fluoxetine
expression
urotensinⅡin inrats
pulmonaryartery
withmonocrotaline--induced
pulmonaryhypertension
Introduction
from Bernin
Urotensin mirabilis 1985,
1I,separatedgilliehthysby
isasomatostatin--likeandisthemost vasoconstric~
neuropeptide potent
toridentifiedSOfar.Anovel
orphanG—protein—coupledreceptor
GPRl4isthe ofurotensin itsre—
specialreceptor II.BothurotensinⅡand
inthe of
are cardiovascularmammali—
eeptorexpressedabundantly system
ananimalsandhuman.urotensinIIcanconstrictmain arteries
pulmonary
inrats.Furthermore,theEmaxwasenhancedinvesselsremovedfrom
rats tochronic lIcanalsoinduce
exposed hypoxia.urotensin proliferation
of smoothmusclecells.In bloodflow—induced
vessels highpulmonary
andchronic modelsofrats,
hypoxia—inducedpulmonaryhypertension
the of themiddleandsmall arteries
urotensinⅡin
expression pulmonary
is withcontrol indicates
highcompared group,whichurotensinⅡcan
contributetOthe of
pathogenesispulmonary
(MCT)——induced modelis
hypertensio
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