zorrimidazolone, a bioactive alkaloid from the non-indigenous mediterranean stolidobranch polyandrocarpa zorritensiszorrimidazolone,生物活性的生物碱沙卡地中海stolidobranch polyandrocarpa zorritensis.pdf

Mar. Drugs 2011, 9, 1157-1165; doi:10.3390/md9061157 OPEN ACCESS Marine Drugs ISSN 1660-3397 /journal/marinedrugs Article Zorrimidazolone, a Bioactive Alkaloid from the Non-Indigenous Mediterranean Stolidobranch Polyandrocarpa zorritensis 1 1 1 2 3 Anna Aiello , Ernesto Fattorusso , Concetta Imperatore , Carlo Irace , Paolo Luciano , Marialuisa Menna 1,*, Rita Santamaria 2 and Rocco Vitalone 1 1 The NeaNat Group, Department of Chemistry of Natural Products, University of Napoli “Federico II”, Via D. Montesano 49, Napoli 80131, Italy; E-Mails: aiello@unina.it (A.A.); fattoru@unina.it (E.F.); cimperat@unina.it (C.I.); rocco.vitalone@unina.it (R.V.) 2 Department of Experimental Pharmacology, University of Napoli “Federico II”, Via D. Montesano 49, Napoli 80131, Italy; E-Mail: carlo.irace@unina.it (C.I.); rita.santamaria@unina.it (R.S.) 3 C.S.I.A.S. (Interdepartmental Service Center for Spectroscopic Analysis), University of Napoli “Federico II”, Via D. Montesano 49, Napoli 80131, Italy; E-Mail: pluciano@unina.it * Author to whom correspondence should be addressed; E-Mail: mlmenna@unina.it; Tel.: +39-081-678-518; Fax: +39-081-678-552. Received: 6 May 2011; in revised form: 31 May 2011 / Accepted: 16 June 2011 / Published: 23 June 2011 Abstract: Chemical analysis of the Mediterranean ascidian Polyandrocarpa zorritensis (Van Name 1931) resulted in the isolation of a series of molecules including two monoindol