肉毒神经毒素的作用机制及研究进展.pdf

2005 12 29 BullAcadM ilM ed Sc,i Dec 2005; Vol 29 No 5 3 , ( 军事医学科学院微生物流行病研究所病原微生物生物安全国家重点实验室, 北京 100071) [ ] 肉毒神经毒素( botulinum neurotoxins, BoNTs)是目前已知的毒力最强的毒素蛋白, 它通过与神经肌肉接头 处的神经元上的受体结合, 抑 神经递质释放而引起松弛性麻痹, 进而导致生物体死亡, 是重要的生物恐怖剂之 一研究 BoNT 的作用机 , 获得具有中和活性的保护性抗体, 对肉毒毒素中毒的防治具有重要意义本文就 BoNT 的作用机 及近年来的研究进展作 一综述 [ ] 肉毒神经毒素; 神经递质; 突触小泡 [ ] R99 . 1 [] A [ ] 1000-5501( 2005) 0 -05 3-04 Advances in research on m echanism s of action of botulinum neurotoxins M EN G L u-L u, YIN Jun ( State Key Laboratory of Pathogens and B iosecurity, Institute ofM icrob iology and Ep idem iology, A cadem y ofM ilitaryM ed-i cal Sciences, Beijing 100071, Ch ina) [ Abstract] Botu linum neurotoxin ( BoNT) is the most potent known tox in affecting hum ans. By b inding to the specific neuronal receptors at neuromuscular junctions( NM J), the BoNT inh ibits the release of neurotransm itters, causes flaccid paralysis and even death of the organ ism s. It is listed as one of them ost dangerous bioterrorism agents. There are great sen- ses to illustrate the m echan ism s of action of BoNT in order to obtain the therapeu tic neutralizing antibody. In th is article, the advances in the research on them echanism s of action of BoNT are reviewed. [ Key words] botulinum neurotoxin; neurotransm itter; synaptic vesicle ( botulinum neurotoxin, BoNT) ( C lostr id ium botulinum ) , 300, [ 1] 3, A- 300, 10 , , ( CDC) [ 2] A , BoNT A ~ G 7 A, B E, F, C DBoNT 3 150 @ 10 , 3 100 @ 10 50 @ 3 10 , , : C , N ( 1) , , , 1 [ 4] 1 BoNT