t cells in anca-associated vasculitis what can we learn from lesional versus circulating t cellst细胞在anca-associated血管炎我们能学习lesional与循环t细胞.pdf

Wilde et al. Arthritis Research Therapy 2010, 12:204 /content/12/1/204 R E V I E W T cells in ANCA-associated vasculitis: what can we learn from lesional versus circulating T cells? 1,2 1 1 1 2 Benjamin Wilde , Marielle Thewissen , Jan Damoiseaux , Pieter van Paassen , Oliver Witzke and Jan Willem Cohen Tervaert*1 WG, ANCA is in most cases directed to proteinase-3 Abstract (PR3) [1]. All three diseases are associated with systemic Anti-neutrophil cytoplasmic antibody (ANCA)- vasculitis and pauci-immune crescentic, necrotizing associated vasculitis (AAV) is a life-threatening glomerulonephritis [2]. In addition, in many patients autoimmune disease characterized by an antibody- with WG or CSS, necrotizing granulomatous infl amma- mediated glomerulonephritis and necrotizing tion of the airways is observed. However, the histological vasculitis. Apart from antibodies, T cells are also fi ndings vary slightly between the disease entities; tissue involved in disease pathogenesis. This review stresses infi ltration with eosinophils is observed mainly in CSS, the hallmarks of T cell-mediated pathology in AAV and whereas neutrophils are found in WG. Often, T cells are highlights the characteristics of lesional and circulating present within these granulomas [3]. In accordance with T cells in the immune response in AAV. Circulating these fi ndings, serum levels of markers of T-cell activity ef ector T-cell popula