crf receptor antagonist astressin-b reverses and prevents alopecia in crf over-expressing micecrf受体拮抗剂在crf过度表达小鼠astressin-b反转,防止脱发.pdf

CRF Receptor Antagonist Astressin-B Reverses and Prevents Alopecia in CRF Over-Expressing Mice 1. 1 . 2 2 3 4 Lixin Wang , Mulugeta Million * , Jean Rivier , Catherine Rivier , Noah Craft , Mary P. Stenzel-Poore , ´ 1 Yvette Tache 1 Division of Digestive Diseases, Department of Medicine, CURE and Center for Neurobiological Stress, David Geffen School of Medicine at University of California Los Angeles, VA Greater Los Angeles Healthcare System, Los Angeles, California, United States of America, 2 Clayton Foundation Laboratories for Peptide Biology, Salk Institute for Biological Studies, San Diego, California, United States of America, 3 Divisions of Dermatology and Infectious Diseases, Department of Medicine, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, David Geffen School of Medicine at University of California Los Angeles, Torrance, California, United States of America, 4 Department of Molecular Microbiology and Immunology, Oregon Health Sciences University, Portland, Oregon, United States of America Abstract Corticotropin-releasing factor (CRF) signaling pathways are involved in the stress response, and there is growing evidence supporting hair growth inhibition of murine hair follicle in vivo upon stress exposure. We investigated whether the blockade of CRF receptors influences the development of hair loss in CRF over-expressing (OE)-mice that display phenotypes of Cushing’s syndrome and chronic stress, including alopecia. The non-selective CRF receptors antagonist, astressin-B (5 mg/ mouse) injected peripherally once a day for 5 days in 4–9 months old CRF-OE alopecic mice induced pigmentation and hair re-growth that was largely retained for