JUNB基因和TOB1基因在肝细胞癌中的表达及意义_张彧.pdf

·2504 · ， JUNB TOB1 张 彧 等 基因和 基因在肝细胞癌中的表达及意义 · ?消化 泌尿系肿瘤? JUNB 基因和TOB1 基因在肝细胞癌中的表达及意义 1 2 3 2 2 2 ， ， ， ， ， 张 彧 陈 铃 何 国珍 邓 伟 张春燕 黄天壬 JUNB and TOB1 gene expression and significance in hepatocellular carcinoma Zhang Yu1 ，Chen Ling2 ，He Guozhen3 ，Deng Wei2 ，Zhang Chunyan2 ，Huang Tianren2 1 The Aff iliated Tumor Hosp ital of Guangxi Medical University ，Guangxi Nanning 530021，China; 2 Guangxi Cancer Institute ，Guangxi Nanning 530021，China; 3 College of Traditional Chinese Medicine of Guangxi ，Guangxi Nanning 530222 ，China． 【Abstract 】 Objective: To explore the role of JUNB genes and TOB1 gene expression in the development of hepato- cellular carcinoma( HCC) ． Methods: By using semi － quantitative reverse transcriptase PCＲ( ＲT － PCＲ) technology to detect 55 cases of liver cancer． 55 patients with other tumor and 33 control for JUNB gene and TOB1 gene expres- sion． Ｒesults: The comparison between peripheral blood JUNB and TOB1 gene expression was no difference ，the ex- pression level of JUNB gene and TOB1 gene in peripheral blood of patients with hepatocellular carcinoma were signifi- cantly higher than that in other groups( P = 0 ． 003 and P = 0 ． 000) ，in the other group there was no difference． Con- clusion : The level of expression of mＲNA JUNB gene and TOB1 gene in the peripheral blood is associated with HCC ， occurrence ，development． 【Key words 】gene; JUNB; TOB1; hepatocellular carcinoma; ＲT － PCＲ Modern Oncology 2013 ，21( 11) : 2504 － 2507 【 】 : JUNB TOB1 (HCC) 。 : 摘要 目的 探讨 基因和 基因的表达在原发性肝细