GRIM19蛋白在非小细胞肺癌组织中的表达及其临床意义.pdf

癌《症》ChineseJournalofCancer，2009，28(4)：431—435 431 ．1】盏床研究 · GRlM．19蛋 白在非小细胞肺癌组织中的表达 及其临床意义 周爱民 ， 赵继京 ， 叶 静 ， 肖卫华 。， DhananjayaV．Kalvakolanu． 刘荣玉 ExpressionandclinicalsignificanceofGRIM-19in non．smalIcellIungcancer Ai—MinZhou，，Ji—Jing Zhao， JingYe，Wei—HuaXiao，。 DhananjayaV．KalvakolanuandRong—YuLiu [Abstract] BackgroundandObjective： Gene associated with retinoid— 1．安徽医科大学第一附属医院 干部 呼吸 内科 ． lntederon—inducedmortality一19 (GRIM一19)isoneofthedeath—reIatedgenes 安徽 合肥 23oo22 Its OverexDressiOn could suppress proliferation and promote apoptosis of 2．安徽中医药高等专科学校 tumOr cells． This study was to investigate the expression and clinical 医疗 系． 安徽 芜湖 241000 significanceofGRlM一19 inprimary non—smallcelllungcancer (NSCLC)． 3．中国科技大学 Methods：The expression of GRIM一19 in 49 specimens of NSCLC with 生命科学学院． correspondinq adjacent normaI lung tissues was examined by 安徽 合肥 230027 4．UniversityofMarylandSchoolof immunohistochemistry． The cellulardistribution ofGRlM一19 was observed Medicine， underIaserscanning confocaImicroscope．Results：GRIM一19wasdominantly USA BaltimoreMaryland 21201 located in the cytoplasm ofnormaIlung cellsbutenriched in the nucleiof 1．DepartmentofGeriatdcRespiratory cancerceIIs． The resultwasverified by Iaserscanning confocaImicroscopy． Medeiinc ， Thepositiverate ofGRlM一19was significantlyhigherin normallung tissues TheFirstAffiliatedHospital， thaninNSCLC (93．8％ vs．55．1％，P0．05)．TheproteinIeveIofGRIM一19in AnhuiMedicalUniversity， Hefei，Anhui，230022