抗菌肽的研究进展和展望.pdf

2009, 43( 10): 11~ 19/, 11 韩文瑜, 孙长江 (, 130062) [] 2009- 09- 18 [] A [] 1002- 1280( 2009) 10- 0011- 09 [] S859. 4 [ ] 耐药性细菌的出现致使现有抗菌药物对细菌感染治疗的疗效低下或无效, 形成的 害日益严重, 迫切需要开发出新型的抗菌制剂高效低毒广谱的抗菌肽作为最有希望代替抗 生素的新药制剂倍受国内外科研工作者的关注, 成为当前的研究热点本文综述了抗菌肽的生 物学特性, 生物学活性及其作用机制, 抗菌肽的筛选策略, 分析了影响抗菌肽应用中存在的问题, 并对其应用前景进行了展望 [] 抗菌肽; 研究进展; 应用前景 R esearch Progress on An tim icrob ial P ep tides and Its D evelopm en t Prospect HAN W en- y , SUN Chang- jiang (College of AnimalScience and VeterinaryM edicine, J ilin University, Changchun 130062; China) Abs tract: The emergence of antib iotic- resistant bacteriamake the bad or invalid therape tic effect of the c rre- ntly sed antib iotics sed to combat bacterial infections, w hich severely harm the h m an and anmi al health, and every effort to develop novel antibacterial agents are in great needed. Antmi icrob ial peptides have emerged as effective broad- spectr m therape tic agentsw ith a prom ising s bstit te for antib iotic, and antmi icrob ial peptides have been a prmi ary foc s of new dr g research worldw ide. This paper deals w ith an overview of the types, bioactivities, antibacterialmechan isms, selection m ethods. The problem s in app lications of the antibacterial pept-i des and prospects for f t re researches are alsom entioned. K ey w ord s: antmi icrobial peptides; research progress; application prospect , , 1 , / 1. 1 抗菌肽的概念与来源分类 ( Antibac- 0(MRSA ) terial peptide) ( Antmi icrobial pep- tide)( Antibiotics peptide), , : ;