血管紧张素ⅱ受体拮抗剂与血管紧张素转化酶抑制剂干预轻中度高血压患者尿酸代谢的对比研究.doc

血管紧张素Ⅱ受体拮抗剂与血管紧张素转化酶抑制剂干预轻中度高血压患者尿酸代谢的对比研究 【关键词】nbsp; 高血压；高尿酸血症；血管紧张素Ⅱ受体拮抗剂；ACEI nbsp;nbsp;nbsp; Angiotensin II receptor antagonist and angiotensin converting enzyme inhibitors interfere with mild to moderate hypertensive patients comparative study of uric acid metabolism nbsp;nbsp;nbsp;nbsp;nbsp;nbsp; 【Abstract】nbsp; Objectivenbsp; To investigate the angiotensin II receptor antagonist （ARB） losartan and angiotensin converting enzyme inhibitors （ACEI） enalapril with the treatment of the hyperuricemia in patients with essential hypertension levels of serum uric acid, and evaluation of its efficacy.Methodsnbsp; A random,double-blind. parallel. control design,198 cases of 1 to 2 grade patients with essential hypertension （with hyperuricemia: male serum uric acid concentrationsgt; 400μmol / L,femalegt; 320μmol / L. BUN,SCR which in the normal range） by two weeks placebo after elution,random divided into losartan group or enalapril group, treatment four weeks. if the blood pressure under control ［systolic blood pressure lt;140 mmHg and （or） diastolic blood pressure lt;90 mmHg］,continue to the original dose treatment four weeks, if blood pressure was not controlled ［systolic blood pressuregt; 140 mmHg and （or） diastolic blood pressuregt; 90 mmHg］ will be above drug dose doubled to four weeks treatment, observation of serum uric acid concentration and blood pressure changes.Resultsnbsp; Losartan randomly selected group 100 cases,enalapril group 98 cases, and treatment earlier, losartan group of four weekends, 8 weekend serum uric acid concentration decreased significantly （Plt;0. 001）, enalapril group had no significant （Pgt;0.05）; Comparison between the two groups: the treatment four weeks .8 weeks serum uric acid concentrations of losartan group was lower than enalapril group （Plt;0.001）.Before treatment: two groups of four weeks. eight weeks systolic and diastolic blood pressure were significantly reduced （Plt;0.0001）. Comparison between the two groups of four weeks,8