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the efficiency of mapping of quantitative trait loci using cofactor analysis in half-sib design的效率的映射使用辅因子分析在数量性状half-sib设计.pdf

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Genet. Sel. Evol. 38 (2006) 167–182 167 c INRA, EDP Sciences, 2006 DOI: 10.1051/gse:2005034 Original article The efficiency of mapping of quantitative trait loci using cofactor analysis in half-sib design a∗ b Goutam Sahana , Dirk Jan de Koning , a a a Bernt Guldbrandtsen , Peter Sørensen , Mogens Sandø Lund a Department of Genetics and Biotechnology, Danish Institute of Agricultural Sciences, Research Centre Foulum, Tjele, 8830, Denmark b Division of Genetics and Genomics, Roslin Institute, Roslin, Midlothian, EH25 9PS, UK (Received 30 August 2005; accepted 14 November 2005) Abstract – This simulation study was designed to study the power and type I error rate in QTL mapping using cofactor analysis in half-sib designs. A number of scenarios were simulated with different power to identify QTL by varying family size, heritability, QTL effect and map density, and three threshold levels for cofactor were considered. Generally cofactor analysis did not increase the power of QTL mapping in a half-sib design, but increased the type I error rate. The exception was with small family size where the number of correctly identified QTL increased by 13% when herit
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